In women who are entering menopause, estrogen levels are either too high or too low. Estrogen influences the production of serotonin - a neurotransmitter that regulates mood. Irritable Men Syndrome or Irritable Male Syndrome (IMS) is the term used to describe the mood swings in men. Although Irritable Male Syndrome is most often caused by high stress and/or low testosterone; high estrogen levels can also cause irritability in men.
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